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Peripheral neurons and adipocytes seem to be significantly affected.25-28 The dideoxynucleosides stavudine and didanosine have been shown to produce significant depletion of mitochondrial DNA in both of these tissues.29,30 The cohort we chose to study consisted of HIV-infected patients exhibiting neurologic toxicity from either stavudine and/or didanosine so that we might examine the effects of micronutrient supplementation on HIV disease progression and on one clinical manifestation of mitochondrial toxicity: distal symmetrical polyneuropathy (DSP)

2022 Mar 30;11(4):673